A section of the M1 by Bricket Wood is due to be closed from tonight as part a programme of resurfacing works.
The Highways Agency is beginning work on the northbound stretch of the motorway between Junctions 6 and 6a between 10pm and 5.30am.
The works are scheduled to go on overnight, Monday to Thursday, until next Tuesday April 15.
During the works motorists will be diverted via A405 North Orbital Road, through Chiswell Green to the Park Street Roundabout, then onto the A414 to rejoin the M1 at junction 8.
Stephen Hall, Highways Agency asset manager, said: "The improvement work will involve repairs and resurfacing on the M1 and A1 northbound which will maintain safety and result in smoother journeys which will benefit all drivers who use the roads to leave London.
"We have planned the work to minimise disruption and that is why it will all take place overnight when traffic flows are lowest. In order to carry out the repairs and resurfacing, the M1 or A1 will be closed overnight with clearly signed diversion routes in place so that road users can continue their journeys."