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Owen Farrell starts at fly-half as Saracens look to overturn defeat against Munster in the Heineken Cup
Joel Tomkins, David Strettle and George Kruis also come into the side.
Munster meanwhile make just one change for the return game with Casey Laulala replacing the injured Keith Earls.
Saracens: A Goode, C Ashton, J Tomkins, B Barritt, D Strettle, O Farrell, R Wigglesworth, R Gill, S Brits, M Stevens, S Borthwick (capt), M Botha, G Kruis, W Fraser, K Brown
Replacements: J Smit, M Vunipola, P du Plessis, E Sheriff, E Joubert, N de Kock, C Hodgson, C Wyles
Munster: F Jones, D Howlett (capt), C Laulala, J Downey, S Zebo, R O'Gara, C Murray, D Kilcoyne, M Sherry, BJ Botha, D O'Callaghan, D Ryan; Dave O'Callaghan, P O'Mahony, J Coughlan.
Replacements: D Varley, W du Preez, S Archer, B Holland, P Butler, D Williams, I Keatley, L O'Dea.