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Charlie Hodgson, Andy Saull, and George Kruis all start for Saracens' clash against London Welsh
In the forwards, John Smit starts at hooker with second row George Kruis and flanker Andy Saull both getting their first run outs of the season.
Gavin Henson will make his first Aviva Premiership start for London Welsh since he suffered a minor fracture to his cheekbone during pre-season as he replaces Gordon Ross at number ten.
Hooker Dan George and centre James Lewis replace Neil Briggs and Sonny Parker, who both picked up injuries against Gloucester.
Kick off at the Kassam Stadium is 2.15pm.
London Welsh: 15.Tom Arscott, 14, Phil MacKenzie, 13. James Lewis, 12. Hudson Tonga’uiha*, 11. Nick Scott, 10. Gavin Henson*, 9. Tyson Keats, 1. Frank Montanella*, 2. Dan George, 3. Paulica Ion*, 4 Jonathan Mills ©, 5. Matt Corker, 6. Daniel Browne, 7. Mike Denbee, 8. Ed Jackson.
Subs: 16. Greg Bateman, 17. Tom Bristow, 18. Arthur Joly, 19. Kirill Kulemin*, Alfie To’oala*, 21. Nick Runciman, 22. Ryan Davis, 23. Seb Jewell.
Saracens: 15. Chris Wyles, 14. David Strettle, 13. Joel Tomkins, 12. Owen Farrell, 11. James Short, 10. Charlie Hodgson, 9. Richard Wigglesworth, 1. Rhys Gill, 2. John Smit, 3. Matt Stevens, 4. Steve Borthwick (c), 5. George Kruis, 6. Will Fraser, 7. Andy Saull, 8. Jackson Wray
Subs: 16. Jamie George, 17. Mako Vunipola, 18. Carlos Nieto, 19. Mouritz Botha, 20. Nick Fenton-wells, 21. Neil De Kock, 22. Kameli Ratuvou, 23. Duncan Taylor