Marcus Rashford starts a three-match domestic ban when Manchester United head to Watford, where Luke Shaw could feature despite sustaining concussion last weekend.
Rashford will be unable to build on his two England goals after being sent off against Burnley, but Jose Mourinho says Shaw could feature as "by the protocol point of view and according to our doctor, he will be free to play".
Ander Herrera (ankle) and Marouane Fellaini (back) are doubts, while Marcos Rojo and Diogo Dalot will step up their return from injury when the Under-23s face Reading today.
Mourinho provided no pre-match update on Phil Jones, who came off with a hamstring complaint in the defeat to Tottenham.
Provisional squad: De Gea, Romero, Grant, Valencia, Darmian, Shaw, Young, Jones, Lindelof, Smalling, Jones, Bailly, Pogba, McTominay, Fred, Pereira, Fellaini, Herrera, Matic, Mata, Lingard, Martial, Sanchez, Lukaku.
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